Thrombosis and Thromboembolism

Thrombosis and Thromboembolism
Thursday–Friday, October 22‑23, 2009
Fairmont Copley Plaza Hotel, Boston, Massachusetts
Course Directors:
Samuel Z. Goldhaber, MD and Paul M Ridker, MD, MPH

Program

Accreditation

Registration

Travel

Faculty

This course, offered only once every 3 years, is intended for all general internists and cardiovascular, peripheral vascular, critical care, pulmonary, surgical, and hematologic specialists who are called upon to care for patients with thromboses in the venous and arterial systems. The course will be interactive with onefourth of the time set aside for active discussion with faculty.

Specific clinical topics to be covered include:

New guidelines to manage acute myocardial infarction, pulmonary embolism, and DVT
Antithrombotic therapy with low molecular weight heparin, fondaparinux, and antiplatelet therapy for acute coronary syndrome
Drug‑eluting coronary stents and percutaneous coronary interventions
Novel drug therapies such as oral anti factor Xa agents, and oral direct thrombin inhibitors
Idiopathic and chronic thromboembolic pulmonary hypertension
Heparin‑induced thrombocytopenia
Diagnosis, treatment, and prevention of venous thromboembolism.

A comprehensive syllabus which includes lecture outlines and up‑to‑date bibliographies will be available to all course participants to help organize a personal review of the field of thrombosis and thromboembolism.

Attendance Limited

Course Program

Print a Course Brochure (PDF)

THURSDAY, OCTOBER 22
6:45 ‑ 7:45	Registration and Breakfast
7:45 ‑ 8:00	*Seating*
8:00 ‑ 8:15	Welcome and Course Objectives Samuel Z. Goldhaber, MD, Paul M Ridker, MD, MPH and Arthur A. Sasahara, MD
Venous Thromboembolism: Perspectives
8:15 ‑ 8:40	History of Venous Thromboembolism Arthur A. Sasahara, MD
8:40 ‑ 8:50	Discussion, Q & A
8:50 ‑ 9:15	Epidemiology of VTE Sam Schulman, MD
9:15 ‑ 9:25	Discussion, Q & A
9:25 ‑ 9:50	Genetics of VTE Paul M Ridker, MD, MPH
9:50 ‑10:00	Discussion, Q & A
10:00 ‑10:25	Diagnosis of DVT Marie Gerhard‑Herman, MD
10:25 ‑10:35	Discussion, Q & A
10:35 ‑11:00	*Coffee Break*
Diagnostic, Etiologic, and Therapeutic Considerations
11:00 ‑11:25	Diagnosis of Pulmonary Embolism Henri Bounameaux, MD
11:25 ‑11:35	Discussion, Q & A
11:35 ‑12:00	Hypercoagulability Kenneth Bauer, MD
12:00 ‑12:10	Discussion, Q & A
12:10 ‑12:35	VTE Treatment: Conventional Pharmacotherapy C. Gregory Elliott, MD
12:35 ‑12:45	Discussion, Q & A
12:45 ‑ 2:00	*Lunch*
Clinical Approach to Disease Management
2:00 ‑ 2:25	Heparin‑Induced Thrombocytopenia and Direct Thrombin Inhibitors Theodore E. Warkentin, MD
2:25 ‑ 2:35	Discussion, Q & A
2:35 ‑ 3:00	VTE: Pregnancy, Birth Control, and Hormone Replacement Therapy Samuel Z. Goldhaber, MD
3:00 ‑ 3:10	Discussion, Q & A
3:10 ‑ 3:35	VTE in Children and Adolescents Cathy G. Rosenfield, MD
3:35 ‑ 3:45	Discussion, Q & A
3:45 ‑ 4:10	Cancer and Thrombosis Craig M. Kessler, MD
4:10 ‑ 4:20	Discussion, Q & A
4:20 ‑ 4:40	*Break for Snacks*
4:40 ‑ 5:05	DVT Thrombolysis Suresh Vendantham, MD
5:05 ‑ 5:15	Discussion, Q & A
5:15 ‑ 5:40	Massive Pulmonary Embolism: Thrombolysis and Surgery Samuel Z. Goldhaber, MD
5:40 ‑ 5:50	Discussion, Q & A
Embolectomy and Pulmonary Hypertension
5:50 ‑ 6:15	Catheter Pulmonary Embolectomy Frederick Resnic, MD, MSc
6:15 ‑ 6:25	Discussion, Q & A
6:25 ‑ 6:50	Chronic Thromboembolic Pulmonary Hypertension Michael J. Landzberg, MD
6:50 ‑ 7:00	Discussion, Q & A
7:00	Adjourn
FRIDAY, OCTOBER 23
Arterial Thrombosis: Fundamental Concepts
8:00 ‑ 8:25	Atherothrombosis Peter Libby, MD
8:25 ‑ 8:35	Discussion, Q & A
8:35 ‑ 9:00	Inflammation and the JUPITER Trial Paul M Ridker, MD, MPH
9:00 ‑ 9:10	Discussion, Q & A
9:10 ‑ 9:35	Acute Coronary Syndromes Elliott M. Antman, MD
9:35 ‑ 9:45	Discussion, Q & A
9:45 ‑10:10	ACE Inhibitors and Angiotensin Receptor Blockade Marc Pfeffer, MD, PhD
10:10 ‑10:20	Discussion, Q & A
10:20 ‑10:45	*Coffee Break*
10:45 ‑11:10	Antiplatelet Therapy Stephen D. Wiviott, MD
11:10 ‑11:20	Discussion, Q & A
11:20 ‑11:45	Peripheral Vascular Disease Marie Gerhard‑Herman, MD
11:45 ‑11:55	Discussion, Q & A
11:55 ‑12:20	Coronary Artery Stents: Drug‑Eluting versus Bare Metal Laura Mauri, MD, MSc
12:20 ‑12:30	Discussion, Q & A
12:30 ‑12:55	Idiopathic Pulmonary Hypertension Michael J. Landzberg, MD
12:55 ‑ 1:05	Discussion, Q & A
1:05 ‑ 2:15	*Lunch*
VTE Prevention
2:15 ‑ 2:40	VTE Prophylaxis Samuel Z. Goldhaber, MD
2:40 ‑ 2:50	Discussion, Q & A
Miniupdates in Thrombosis and Thromboembolism
2:50 ‑ 3:15	Vascular Medicine Quiz Joshua A. Beckman, MD
3:15 ‑ 3:40	Novel Anticoagulants Jeffrey Weitz, MD
3:40 ‑ 3:50	Discussion, Q & A
3:50 ‑ 4:15	Optimal Duration of Anticoagulation for VTE Clive Kearon, MD
4:15 ‑ 4:25	Discussion, Q & A
4:25 ‑ 4:50	IVC Filters Piotr Sobieszczyk, MD
4:50 ‑ 5:00	Discussion, Q & A
5:00	Adjourn

Program changes/substitutions may be made without notice.

ACCREDITATION

Harvard Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Harvard Medical School designates this educational activity for a maximum of 16 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

REGISTRATION INFORMATION

Register Online

Register by Mail (PDF)

Tuition Fees
Physicians			$525.00 (USD)
Past Attendees, Residents/Fellows in Training*, Nurses, Allied Health Professionals			$425.00 (USD)

GROUP RATE INQUIRIES
By phone: (617) 384-8600, Monday–Friday, 10 AM to 4 PM (EST) or by email: hms-cme@hms.harvard.edu

PAYMENT INFORMATION
All foreign payments must be made by a draft on a United States Bank or by Visa or MasterCard.

If paying by CHECK, please make payable to Harvard Medical School and mail with completed registration form to Harvard Medical School–Department of Continuing Education, PO Box 825, Boston, MA 02117-0825.

If paying by CREDIT CARD, please register online via this REGISTER NOW link.

Telephone or mail-in registration with credit card payment is not accepted.

Inquiries should be directed to the above address, made by phone: (617) 384-8600, Monday–Friday, 10 AM to 4 PM (EST), or by email: hms-cme@hms.harvard.edu

Upon receipt of registration a confirmation will be mailed to the address listed on the form.

TUITION REFUND POLICY

A handling fee of $60 is deducted for cancellation. Refund requests must be received by mail one week prior to the course. No refunds will be made thereafter.

Group Rate Discount Tuition Policy

Group tuition rates are offered and based on the collective registration of all group members. Should a group member decide to withdraw their enrollment from the course the remaining group members are responsible to find a replacement in order to maintain their group discount status. If the remaining group members can not find a replacement prior to the start of the course, they will be invoiced and required to pay in full the difference between the individual tuition rate and the group discount rate.

Last update 05.08.09

COURSE LOCATION

All sessions will be held at
The Fairmont Copley Plaza Hotel
138 St. James Avenue
Boston, MA 02116
(Telephone: 617-267-5300)
www.fairmont.com/copleyplaza

ACCOMMODATIONS

Hotel rooms in Boston are limited. You are urged to make your reservations early.

A limited number of rooms have been reserved at the Fairmont Copley Plaza (617‑267‑5300 or 800‑795‑3906) until September 30, 2009. Please specify that you are enrolled in this course to receive a reduced room rate of $293 Single/Double, $313 Deluxe.

You may also make hotel reservations online at https://resweb.passkey.com/go/HMSBWHthrombosis09. To ensure you receive the group discounted rate, it is recommended that you make your reservations as soon as you receive confirmation of enrollment, as these discounted rooms often sell out before the date noted above.

A map of Boston listing local hotels will be sent with your confirmation of enrollment. For additional housing assistance, call Boston Reservations at (617) 332‑4199.

Last update 05.12.09

TRAVEL

Please do not make non-refundable airline reservations until you have been confirmed into your course. You can make your airline reservation by calling: the HMS Travel Desk toll free 1-877-4HARVMD (1-877-442-7863) Monday–Friday 9 AM–8 PM (EST). From outside the U.S., Canada and Virgin Islands, please call 617-559-3764.

FACULTY

GUEST FACULTY
HENRI BOUNAMEAUX, MD Chief, Division of Angiology and Hemostasis; Chairman, Department of Internal Medicine, Hôpital Cantonal, University Hospitals of Geneva Henri Bounameaux, MD graduated as MD in Basle, Switzerland in 1978. Board certified in internal medicine and vascular medicine, he became Director of the Division of Angiology and Hemostasis at the University Hospitals of Geneva in 1993. Since 2002, he is Professor of medicine at the University of Geneva and Chairman of the Department of Medicine. His research interests cover all aspects of venous thromboembolism. He has authored almost 300 papers in peer-reviewed journals and 100 reviews, didactic papers and book chapters. He acts as a reviewer for most important publications in the fields of internal and vascular medicine. Professor Bounameaux has received many awards including the Karl Rohr Prize of the Swiss Society of Haematology (1991), the Award of the Swiss Society of Angiology (1991), the Theodor Naegeli International Thrombosis Award (1995), the EDMA Award of the International Federation of Clinical Chemistry (1999) and an Investigator Recognition Award from the International Society on Thrombosis and Haemostasis (ISTH) in 2003. He has been the President of the ISTH Congress in 2007 in Geneva and is presently Chairman elect of ISTH Council.
CLIVE KEARON, MD Head, Clinical Thrombosis Service, Henderson General Hospital; Professor of Medicine, McMaster University
C. GREGORY ELLIOTT, MD Chairman, Department of Medicine; Professor with Tenure, Intermountain Medical Center; Associate Chairman, Department of Internal Medicine, University of Utah School of Medicine
CRAIG M. KESSLER, MD, MACP Director, Clinical Coagulation Laboratory, Division of Laboratory Medicine, Georgetown University Hospital; Professor of Medicine and Pathology Director, Division of Coagulation, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center
CATHY G. ROSENFIELD, MD Director, Pediatric Hematology/Oncology Clinic ‑ Hemophilia; Interim Chief for Pediatric Hematology/Oncology, The Floating Hospital for Children at Tufts Medical Center; Assistant Professor in Pediatrics, Tufts University School of Medicine
SAM SCHULMAN, MD Director, Clinical Thromboembolism Program, Hamilton Health Sciences, Hamilton General Hospital; Professor of Medicine, McMaster University
SURESH VEDANTHAM, MD Professor, Radiology, Division of Diagnostic Radiology, Interventional Radiology Section, Mallinckrodt Institute of Radiology; Associate Professor, Surgery, Washington University School of Medicine at St. Louis
THEODORE E. WARKENTIN, MD, FACP, FRCPC Regional Director, Transfusion Medicine, Professor, Department of Medicine, Professor, Department of Pathology and Molecular Medicine, McMaster University
JEFFREY WEITZ, MD Director, Experimental Thrombosis and Atherosclerosis Programme, Henderson Research Center; Professor of Medicine, McMaster University
HARVARD FACULTY
ELLIOTT M. ANTMAN, MD
KENNETH BAUER, MD
JOSHUA A. BECKMAN, MD
MARIE GERHARD-HERMAN, MD
SAMUEL Z. GOLDHABER, MD
MICHAEL J. LANDZBERG, MD
PETER LIBBY, MD
LAURA MAURI, MD, MSC
MARC A. PFEFFER, MD, PHD
FREDERIC S. RESNIC, MD, MSC
PAUL M RIDKER, MD, MPH
ARTHUR SASAHARA, MD
PIOTR SOBIESZCZYK, MD
STEPHEN D. WIVIOTT, MD

Last updated 05.01.09

Earn up to
16 CME Credits

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Register Online (CC)

Meet the Course Directors

Samuel Z. Goldhaber, MD
Dr. Goldhaber is Professor of Medicine at Harvard Medical School and is a Senior Staff Member of the Cardiovascular Medicine Division at Brigham and Women’s Hospital (BWH). He is Director of the BWH Venous Thromboembolism Research Group and serves as Principal Investigator of a broad range of randomized clinical trials and observational studies related to the prevention, treatment, and epidemiology of venous thromboembolism.
Dr. Goldhaber has authored more than 400 publications. The March 10, 2005, New England Journal of Medicine published his large clinical trial that described a new method using electronic, computerized alerts to enhance venous thromboembolism prophylaxis. This intervention reduced symptomatic DVT and PE by 41%, without an increase in bleeding complications.
In 2008, the National Heart Lung and Blood Institute appointed him to serve on the Steering Committee of its new multicenter trial: “A Randomized Controlled Clinical Trial of Clarification of Optimal Anticoagulation through Genetics.” Dr. Goldhaber also serves as Chair of the Steering Committee of the investigator-initiated, NHLBI-sponsored “ATTRACT Trial”.
Dr. Goldhaber is President and one of four Founding Directors of the nonprofit North American Thrombosis Forum (www.NATFonline.org).

Paul M Ridker, MD, MPH
Dr. Ridker is the Eugene Braunwald Professor of Medicine at the Harvard Medical School and directs the Center for Cardiovascular Disease Prevention at the Brigham and Women’s Hospital in Boston which focuses on molecular and genetic epidemiology of cardiovascular diseases. A graduate of Brown University, Harvard Medical School, and Harvard School of Public Health, Dr. Ridker’s research brings together classical tools of population based epidemiology with emerging genetic and molecular techniques designed to improve prediction and prevention of heart attack and stroke. Dr. Ridker’s research efforts are primarily supported by grants from the National Heart, Lung, and Blood Institute, the Leducq Foundation, and the Donald W Reynolds Foundation. Dr. Ridker has been the recipient of multiple awards including an Established Investigator Award (American Heart Association), a Distinguished Investigator Award (Doris Duke Foundation), and elected membership to the American Society for Clinical Investigation, the American Epidemiological Society, and the American Association of Physicians. Citing his pioneering work on inflammation, C-reactive protein (CRP), and heart disease, Time Magazine honored Dr. Ridker as one of America’s Ten Best Researchers in Science and Medicine in 2001 and as one of the “Time 100 Most Influential” in 2004. In 2008, Dr Ridker presented results of the multi-national landmark JUPITER trial demonstrating the life-saving benefits of statin therapy among those with low cholesterol but elevated CRP levels, a prevention strategy that will result in 250,000 fewer heart attacks, strokes, and cardiovascular deaths in the United States alone.

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